Manchester United came from behind to win at Deepdale and set up a mouthwatering FA Cup quarter-final showdown against Arsenal.
Scott Laird had given Preston a shock lead at the beginning of the second-half when his deflected drive went through David de Gea.
However, Ander Herrera hauled the visitors level on 65 minutes when he fired home only his fourth goal for the club.
Marouane Fellaini put Louis van Gaal's men ahead midway through the second period before Wayne Rooney's late penalty sealed their spot in the last eight.
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